Factors associated with incomplete immunologic recovery in HIV-infected patients with clinical and virologic success after 10 years of antiretroviral therapy: a prospective cohort study
Background: HIV
infected patients with virologic suppression and absence of recent clinical
events after 10 years of antiretroviral therapy might have incomplete immune
recovery.
Methods: Prospective
APROCO-COPILOTE cohort of patients started on protease inhibitor (PI)-containing
regimen in 1997-1999. Evaluation of patients with 10 year follow-up and
clinico-virological success. Impact of antiretroviral treatment history on the immunologic
response measured at 10 years was assessed by multivariate logistic regression models.
Outcome variables were CD4 response (CD4 cell counts > 500/ µl)
and complete immunologic response
(CD4 cell counts > 500/ µl
and CD4:CD8 ratio > 1).
Results: Among
the 610 patients (median follow-up on antiretroviral therapy: 120.3 months (IQR
119.5-121.5), 399 had no clinical progression and sustained virologic
suppression during the last year. Median baseline values were : age 38.5 years,
CD4 254/ µl, HIV RNA 4.6 log10 c/mL. Initial PI was unboosted indinavir
or nelfinavir (77%). Of the 399 patients, 67% had CD4 response and 20% complete
immunologic response. In multivariate analyses, factors associated with
incomplete CD4 response were older age at baseline (OR 2.62, 95% CI 1.56-4.40),
absence of CD4 recovery > 500/µl at month (M)8 (OR 2.39,
95% CI 1.11-5.12) or M12 (OR 4.57, 95% CI 2.23-9.36), not being antiretroviral-naÏve
at time of PI-containing HAART initiation (OR 1.89, 95% CI 1.12-3.22) and a
higher number of treatment sequences (OR 2.16, 95% CI 1.27-3.67). Factors associated
with incomplete immunologic response were non-African origin (OR 0.29, 95% CI
0.11-0.76), low CD4:CD8 ratio at M4 (OR 9.37, 95% CI 1.55-56.6) or M12 (OR
3.72, 95% CI 1.08-12.8), and longer duration of antiretroviral treatment
interruption (OR 7.75, 95% CI 1.84-32.7), while baseline CD4 and CD4:CD8 ratio
were not predictors of 10 year immunologic outcomes.
Conclusions: In
this population having started antiretroviral therapy with first generation PI,
long-term immunologic recovery was rarely complete after 10 years of
antiretroviral therapy despite clinical and virological success. Failure to
achieve long-term immunologic response was not associated with baseline
immunological parameters but with immunologic response during the first year of
treatment, as well as with less complex therapeutic history and shorter
duration of treatment interruptions.
F. Raffi1, A. Perrier2, V. Le Moing3, A. Assuied2, B. Spire4, C. Michelet5, R. Verdon6, C. Jadand7, G. Chêne2, C. Leport7, and the ANRS CO8 APROCO-COPILOTE Study Group
1Université de Nantes, ID, Nantes, France, 2INSERM U897 Epidemiologie-Biostatistiques, Bordeaux, France, 3Université de Montpellier, Infectious Diseases, Montpellier, France, 4INSERM U912, Marseille, France, 5Université de Rennes, Infectious Diseases, Rennes, France, 6Université de Caen, Infectious Diseases, Caen, France, 7INSERM, UMR 1137, site Bichat, Paris, France